Meningococcal Vaccine Based on Lipooligosaccharide (LOS) and Neisseria Meningitidis Protein
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United States of America Patent
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Issued Date -
Jun 21, 2012
app pub date -
May 12, 2010
filing date -
May 14, 2009
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Abstract
The invention relates to a vaccine against N. meningitidis infections, comprising (i) an N. meningitidis LOS especially consisting of a lipid A, an inner core, and an L8-type α chain in which the heptose II residue of the inner core (a) carries a phosphoethanolamine (PEA) substituent in position O-3, and does not carry a PEA substituent in positions O-6 and O-7, or (b) carries a phosphoethanolamine (PEA) substituent in position O-3 and in position O-6 or O-7; and (ii) the lipidated sub-unit B (TbpB) of the receptor of the human transferrine of an N. meningitidis strain or a lipid fragment of said TbpB.
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