Phage-GnRH Constructs, Their Mimics, Antigenic Compositions, and Sequences for Immunocontraception of Animals and Other Applications

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United States of America Patent

APP PUB NO 20120156215A1
SERIAL NO

13165422

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Abstract

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Disclosed are recombinant bacteriophage constructs and related heterologous peptide sequences for contraception in animals. The disclosed recombinant phage constructs bind to antibodies against gonadotropin releasing hormone (GnRH) and can be administered to an animal to generate an immune response against GnRH, including generating anti-GnRH antibodies. The disclosed recombinant phage may comprise an amino acid sequence of gonadotropin releasing hormone (GnRH), epitopic fragments, variants, or functional mimics thereof. Also disclosed are methods for making and selecting such recombinant phage constructs and compositions that comprise such constructs (e.g., compositions for inducing an immune response against GnRH including pharmaceutical or veterinary compositions used as vaccines). Also disclosed are recombinant polynucleotides comprising genomic nucleic acid of the recombinant phage constructs disclosed herein.

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Patent Owner(s)

Patent OwnerAddress
AUBURN UNIVERSITY570 DEVALL DRIVE SUITE 102 AUBURN AL 36832

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cox, Nancy R Auburn, US 4 47
Petrenko, Valery A Auburn, US 13 96
Samoylov, Alexandre M Auburn, US 12 127
Samoylova, Tatiana I Auburn, US 12 105

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