TARGETED GENOMIC REARRANGEMENTS USING SITE-SPECIFIC NUCLEASES
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United States of America Patent
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Issued Date -
Jun 14, 2012
app pub date -
Jun 11, 2010
filing date -
Jun 11, 2009
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Abstract
The present invention relates to a method for genomic DNA rearrangements, and more particularly, to a method for deletion, duplication, inversion, replacement, or rearrangement of genomic DNA using pairs of site-specific nucleases targeting two or more sites in the genome, a cell in which genomic DNA is deleted, duplicated, inverted, replaced, or rearranged by the same method, and a method for expressing the site-specific nucleases in cells. Further, the present invention relates to a method for inserting synthetic DNA molecules into the genome using site-specific nucleases targeting a pre-determined site in the genome, a cell in which DNA insertion occurs by the same method, and a method for expressing the site-specific nucleases in cells.
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