MONOMETHYLVALINE COMPOUNDS CAPABLE OF CONJUGATION TO LIGANDS
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United States of America Patent
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app pub date -
Feb 15, 2012
filing date -
Nov 6, 2003
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Abstract
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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