UNIVERSAL INFLUENZA VACCINE BASED ON RECOMBINANT MODIFIED VACCINE ANKARA VIRUS (MVA)
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United States of America Patent
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Issued Date -
Jun 7, 2012
app pub date -
May 17, 2010
filing date -
May 18, 2009
priority date (Note) -
Abandoned
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Abstract
The present invention relates to a novel influenza vaccine, a novel plasmid for preparing the same and a novel dosage form comprising the same. The present invention in particular relates to a recombinant modified vaccinia Ankara (MVA) virus comprising and capable of simultaneously expressing a cassette of at least four foreign genes from influenza virus, specifically an avian influenza virus, wherein the said genes are inserted at a non-essential site, within the MVA genome. The invention further relates to a recombinant modified vaccinia Ankara (MVA) virus comprising and capable of simultaneously expressing a cassette of not less than two foreign genes from influenza virus, wherein the said genes are inserted at a non-essential site, within the MVA genome, with the provision that at least one foreign gene is either PB2 or M2e. The invention also provides composition and methods of making the universal influenza vaccine.
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