Polypeptides that Bind TRAIL-R1 and TRAIL-R2
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United States of America Patent
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Issued Date -
May 31, 2012
app pub date -
Jan 26, 2012
filing date -
Oct 10, 2008
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Abandoned
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Abstract
Agonists for TRAIL death receptors including polypeptides having a multimerizing, e.g. trimerizing, domain and a polypeptide sequence that binds to at least one of TRAIL death receptors TRAIL-R1 and TRAIL-R2. Agonists are described that do not bind to TRAIL decoy receptors. The multimerizing domain may be derived from human tetranectin. The agonists can induce apoptosis in pathogenic cells expressing a TRAIL death receptor. Pharmaceutical compositions are described for treating diseases associated with cells expressing DR4 and DR5, such as tumor cells. Methods for selecting polypeptides and preparing multimeric complexes.
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