CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES

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United States of America Patent

APP PUB NO 20120129841A1
SERIAL NO

13274412

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and compositions, and methods for the administration and use of those compounds. provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing serum, plasma, and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

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Patent Owner(s)

Patent OwnerAddress
PTC THERAPEUTICS INC100 CORPORATE COURT SOUTH PLAINFIELD NJ 07080-2449

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cao, Liangxian Parlin, US 32 521
Davis, Thomas South Orange, US 57 482
Hirawat, Samit South Plainfield, US 31 228
Miller, Langdon Lebanon, US 38 313
Weetall, Marla L Morristown, US 33 238

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