NOVEL POLYNUCLEOTIDE MOLECULES FOR ENHANCED GENE EXPRESSION
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United States of America Patent
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Issued Date -
May 24, 2012
app pub date -
Jun 22, 2010
filing date -
Jun 22, 2009
priority date (Note) -
Abandoned
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Abstract
Disclosed herein is an isolated polynucleotide molecule encoding protein such as erythropoietin or structural variants, comprising an expression regulating nucleotide sequence operatively linked to a nucleotide sequence(s) encoding said proteins. The said expression regulatory region comprises of Exon A and at least proximal region of Intron A of Major Immediate Early Region of human Cytomegalovirus or its functional variants which when transfected into host cells results in many fold increase in expression of the protein.
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