Methods of Controlling Cell Proliferation
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United States of America Patent
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Issued Date -
May 24, 2012
app pub date -
Jul 16, 2010
filing date -
Jul 17, 2009
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Abandoned
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Abstract
The present disclosure provides methods for increasing self-renewal/expansion of stem cells. The present disclosure provides methods of reducing uncontrolled cell proliferation. The present disclosure provides methods of identifying agents that modulate Notch1/-catenin binding, and methods of identifying agents that inhibit enzyme-mediated cleavage of Notch1 intracellular domain from Notch1 transmembrane domain.
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