COMPOSITIONS AND METHODS FOR THE REMOVAL OF BIOFILMS
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United States of America Patent
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Issued Date -
May 24, 2012
app pub date -
Sep 9, 2011
filing date -
Sep 9, 2010
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Abstract
Methods of breaking down a biofilm or inhibiting, preventing or treating a microbial infection that produces a biofilm are disclosed, which involves administration of a polypeptide that has one or more HMG-box domains to a subject suffering from the infection or having the biofilm. By competing with microbial proteins that bind to DNA scaffold in the biofilm, these polypeptides destabilize the biofilm leading to destruction and removal of the biofilm by the immune system.
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