Modified non-cytotoxic proteases
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Dec 26, 2017
Grant Date -
May 24, 2012
app pub date -
Dec 16, 2009
filing date -
Feb 23, 2009
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention relates to a modified polypeptide comprising a non-cytotoxic protease, a translocation domain, a destructive protease cleavage site and a Targeting Moiety that binds to a Binding Site on a nerve cell, wherein after cleavage of the destructive cleavage site the polypeptide has reduced potency. The destructive cleavage site is recognized and cleaved by a protease present at or in an off-site target cell, and, in one embodiment, the polypeptide is a modified clostridial neurotoxin. The present invention also relates to the use of said polypeptides for treating a range of conditions, and to nucleic acids encoding said polypeptides.
First Claim
Other Claims data not available
Family
International Classification(s)
- 2009 Application Filing Year
- A61K Class
- 10313 Applications Filed
- 6747 Patents Issued To-Date
- 65.43 % Issued To-Date
Cited Art Landscape
Patent Citation Ranking
- 1 Citation Count
- A61K Class
- 45.09 % this patent is cited more than
- 8 Age
Maintenance Fees
| Fee | Large entity fee | small entity fee | micro entity fee | due date |
|---|---|---|---|---|
| 7.5 Year Payment | $3600.00 | $1800.00 | $900.00 | Jun 26, 2025 |
| 11.5 Year Payment | $7400.00 | $3700.00 | $1850.00 | Jun 26, 2029 |
