Importance

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Abstract

The invention concerns dual molecules corresponding to formula (I): in which: A represents a molecular residue with antimalarial activity of formula (IIa) or (IIIa) or a residue facilitating bioavailability; B represents a cycloalkyl group potentially substituted, or B represents a bi- or tricyclic group capable of being substituted, or B represents 2 cycloalkyl groups linked together through either a single bond or an alkylene chain; m and n represent independently of one another 0, 1 or 2; R₅ represents a hydrogen atom, an alkyl, cycloalkyl or C_1-3-alkylene-cycloakyl group; Z₁ and Z₂ represent an alkyl radical, the group Z₁+Z₂+C_i+C_j representing a mono- or polycyclic structure, with one of the Z₁ or Z₂ being able to represent a single bond; R₁ and R₂, identical or different, represent a hydrogen atom or a functional group capable of increasing hydrosolubility; R_x and R_y forming together a cyclic peroxide including 4 to 8 links and including 1 or 2 additional oxygen atoms in the cyclic structure, possibly substituted by one or more R₃ groups; as a base or a salt to be added to an acid, as a hydrate or solvate, in racemic form, isomers and their mixtures, in addition to their diasteroisomers and their mixtures. Preparation method and use as medications with antimalarial activity.

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First Claim