CONJUGATION METHOD
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United States of America Patent
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Issued Date -
May 10, 2012
app pub date -
Jul 15, 2010
filing date -
Jul 17, 2009
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Abandoned
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Abstract
A process for the conjugation of a polymer to a protein, which comprises reacting a polymeric conjugating agent with said protein, in an aqueous medium, in the presence of an amphipathic sugar polymer. The process is particularly useful when conjugating PEG to proteins, particularly to proteins which have previously proved difficult to PEGylate in acceptable yields, for example INF-β.
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