Compositions and Methods for Modulating Immunodeficiency Virus Transcription
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United States of America Patent
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Issued Date -
May 3, 2012
app pub date -
Oct 4, 2011
filing date -
Oct 7, 2010
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Abandoned
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Abstract
The present disclosure provides methods of modulating immunodeficiency virus transcription, involving modulating enzymatic activity and/or levels of a lysine-specific demethylase-1 (LSD1) polypeptide and/or LSD1-mediated demethylation of methylated Tat. The present disclosure also provides method of identifying agents that modulate LSD1-mediated demethylation of a human immunodeficiency virus (HIV) Tat polypeptide.
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