Mutant Glucose Dehydrogenase
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United States of America Patent
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Issued Date -
May 3, 2012
app pub date -
Oct 26, 2011
filing date -
Oct 27, 2010
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Abstract
A mutant glucose dehydrogenase having an amino acid sequence at least 80% identical to SEQ ID NO:3 and having glucose dehydrogenase activity, wherein amino acid residues corresponding to positions 326, 365 and 472 of said amino acid sequence are replaced with glutamine, tyrosine and tyrosine, respectively, and wherein said mutant glucose dehydrogenase shows an improved substrate specificity to glucose and a reduced reactivity to disaccharides.
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