USE OF CYTOPLASMIC C-MYC FOR REGULATING IMMUNE RESPONSES
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United States of America Patent
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Issued Date -
May 3, 2012
app pub date -
Oct 26, 2011
filing date -
Oct 27, 2010
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Abandoned
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Abstract
The subject invention provides novel uses of cytoplasmic c-Myc for modulation of innate immune responses. The invention is based, at least in part, on the surprising discovery that cytoplasmic c-Myc, instead of nuclear c-Myc, modulates pro-inflammatory immune responses via its role as a positive feedback regulator. Specifically, the subject invention provides methods for treatment or amelioration of inflammatory diseases and/or immune disorders via inhibition c-Myc expression or its activity. Also provided are methods for the development of therapeutic agents for treating infection, inflammation, immune diseases and autoimmune diseases.
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