COMBINATORIAL LIBRARIES OF PROTEINS HAVING THE SCAFFOLD STRUCTURE OF C-TYPE LECTIN-LIKE DOMAINS
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United States of America Patent
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Issued Date -
Apr 19, 2012
app pub date -
Jun 8, 2011
filing date -
Dec 13, 2000
priority date (Note) -
Abandoned
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Abstract
Novel polypeptides having the scaffold structure of a C-type lectin-like domain (CTLD) and a randomized loop region for specifically binding a variety of target compounds and also provides nucleic acids encoding the polypeptides. Combinatorial CTLD libraries, methods for constructing the libraries, and methods for screening the libraries to identify and isolate the novel CTLD polypeptides. Libraries of nucleic acids encoding polypeptides having a scaffold CTLD with a randomized loop region, as well as nucleic acid sequences, vectors, and methods for preparing and expressing the libraries. Exemplary nucleic acids useful in the combinatorial libraries are derived from tetranectin and other proteins having a CTLD.
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