Gene Knockout Mesophilic and Thermophilic Organisms, and Methods of Use Thereof

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United States of America Patent

APP PUB NO 20120094343A1
SERIAL NO

13129085

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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One aspect of the invention relates to a genetically modified thermophilic or mesophilic microorganism, wherein a first native gene is partially, substantially, or completely deleted, silenced, inactivated, or down-regulated, which first native gene encodes a first native enzyme involved in the metabolic production of an organic acid or a salt thereof, thereby increasing the native ability of said thermophilic or mesophilic microorganism to produce lactate or acetate as a fermentation product. In certain embodiments, the aforementioned microorganism further comprises a first non-native gene, which first non-native gene encodes a first non-native enzyme involved in the metabolic production of lactate or acetate. Another aspect of the invention relates to a process for converting lignocellulosic biomass to lactate or acetate, comprising contacting lignocellulosic biomass with a genetically modified thermophilic or mesophilic microorganism.

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Patent Owner(s)

Patent OwnerAddress
LALLEMAND HUNGARY LIQUIDITY MANAGEMENT LLC1138 BUDAPEST

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Caiazza, Nicky C Rancho Santa Fe, US 14 58
Hogsett, David A Grantham, US 11 107
Rajgarhia, Vineet Lebanon, US 31 502
Shaw,, IV Arthur J West Lebanon, US 43 141

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