METHOD IN A CHROMATOGRAPHY SYSTEM
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United States of America Patent
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Issued Date -
Apr 19, 2012
app pub date -
Jun 21, 2010
filing date -
Jun 26, 2009
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Abstract
A method for determining binding capacities of a chromatography column (1; 39, 47, 59; 107, 109, 111, 113), comprising: detecting a feed signal (21; 201) representative of the composition of a feed material provided to the inlet of the column; detecting an effluent signal (23; 203, 205, 207, 209) representative of the composition of the effluent from the column; using the feed signal and the effluent signal to determine binding capacities of the column. And a method for controlling a chromatography system comprising at least one column, comprising the steps of: determining binding capacities of the at least one chromatography column according to above; and controlling the start and stop of the different chromatography process steps according to the determined binding capacities.
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