CRIPTO ANTAGONISM OF ACTIVIN AND TGF-B SIGNALING
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United States of America Patent
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Issued Date -
Apr 12, 2012
app pub date -
Oct 19, 2011
filing date -
Sep 15, 2003
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Abandoned
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Abstract
Cripto, a developmental oncoprotein, antagonizes activin and TGF-b signaling by forming a complex with activin and TGF-b and their type II receptors. This complex precludes the formation of a functional activin/TGF-b•type II•type I complex, thereby blocking the signaling of activin and TGF-b. Cripto may be generally capable of blocking antiproliferative Smad2/3 signals and provides a novel mechanism of oncogenic action with multiple therapeutic implications. Inhibiting the formation of Cripto and activin/TGF-b complex may enhance antiproliferative effects of activin and TGF-b.
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