Diagnostic Imaging for Age-Related Macular Degeneration (AMD) Using Second Harmonic Generation (SHG) Techniques
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Oct 20, 2011
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May 25, 2006
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Abstract
A system for treating age-related macular degeneration includes an agent with non-centro symmetric molecules_for marking a region of diseased tissue. An optical assembly focuses the laser beam to a plurality of focal points in the region of diseased tissue, each focal point having a volumetric measurement of about 2 μm×2 μm×20 μm. Due to an increased concentration of photons in the relatively small volume of each focal point, two photons interact with a single molecule of the marking agent, within a very short interval of time (e.g. 10−13 sec). The resultant excited electron state (e.g. 3 eV) is sufficient to induce the marking agent to convert oxygen in a manner that causes the oxygen to kill the diseased tissue. Also, an interaction between photons and a non-centro symmetric molecule in the marking agent will cause a Second Harmonic Generation (SHG) response that can be used for imaging purposes.
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