Biomolecular Labelling Using Multifunctional Biotin Analogues

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United States of America Patent

APP PUB NO 20120083599A1
SERIAL NO

13257562

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Abstract

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Novel biotin analogues, such as 2-Azidobiotin, comprising the ureido ring of natural biotin with the thiophene ring, optionally modified, and a modified sidechain having a functional end group, preferably selected from the group consisting of a carboxylic acid, amine, alcohol, thiol, aldehyde and a halide, and at least one bio-orthogonally reactive chemical group located elsewhere in the sidechain. The analogues are used for labelling target structures and biomolecules, such as peptides and proteins in vitro or in vivo.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF NOTTINGHAMNOTTINGHAMSHIRE ENGLAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Drewe, William C Nottingham, GB 1 2
Thomas, Neil R Nottingham, GB 1 2
Yong-Qing, Yang Nottingham, GB 1 2

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