Downregulation of SPY1 by p53 as an essential component of p53-mediated effects
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United States of America Patent
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Issued Date -
Apr 5, 2012
app pub date -
Aug 16, 2011
filing date -
Aug 17, 2010
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Abandoned
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Abstract
The present invention relates to a novel method of treating or preventing cancer as well as a novel method for diagnosing or monitoring cancer, wherein the cancer is caused by delayed entry to cellular senescence. More particularly, the present invention relates to a novel method of treating or preventing cancer, comprising a step of administering an agent selected to degrade, inhibit or downregulate Spy1 in a cell. The present invention also relates to a novel method of diagnosing or monitoring cancer, comprising the steps of treating a cell with UV radiation and measuring amounts of a Spy1 protein and a p53 protein, or a ratio thereof.
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