Dry eye animal model
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United States of America Patent
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Issued Date -
Mar 29, 2012
app pub date -
Sep 21, 2011
filing date -
Sep 24, 2010
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Abandoned
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Abstract
A first embodiment is a dry eyed animal model method by peri or post-menopausal estrogen-treated rats have decreased tear production wherein the menopausal rat may be produced by ovariectomy Chronic estrogen exposure can decrease tear production in rats receiving a nine month course of estrogen versus placebo treatment after ovariectomy. The aged, chronically estrogen-treated female rats can provide a suitable model for the study of KCS and its treatment.
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