Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles

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United States of America Patent

PATENT NO 8718946
APP PUB NO 20120077199A1
SERIAL NO

13239070

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Abstract

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A method provides an index that is indicative of the state of a subject, as to a biological condition, based on a sample from the subject. An embodiment of this method includes: deriving from the sample a profile data set, the profile data set including a plurality of members, each member being a quantitative measure of the amount of a distinct RNA or protein constituent in a panel of constituents selected so that measurement of the constituents enables evaluation of the biological condition; and in deriving the profile data set, achieving such measure for each constituent under measurement conditions that are substantially repeatable; and applying values from the profile data set to an index function that provides a mapping from an instance of a profile data set into a single-valued measure of biological condition, so as to produce an index pertinent to the biological condition of the subject.

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Patent Owner(s)

Patent OwnerAddress
LIFE TECHNOLOGIES CORPORATIONCARLSBAD CA 92008

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bankaitis-Davis, Danute Longmont, US 16 86
Bevilacqua, Michael Boulder, US 12 94
Cheronis, John Conifer, US 6 25
Tryon, Victor Loveland, US 26 389

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