IN VIVO SCREENING MODELS FOR TREATMENT OF isoQC-RELATED DISORDERS
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United States of America Patent
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Issued Date -
Mar 22, 2012
app pub date -
Sep 2, 2011
filing date -
Jan 19, 2007
priority date (Note) -
Abandoned
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Abstract
A transgenic non-human animal for overexpressing isoQC, comprising cells containing a DNA transgene encoding human isoQC, characterized in that said human isoQC comprises the amino acid sequence of SEQ ID NO: 1 or an amino acid sequence having at least 75% sequence identity to the amino acid sequence of SEQ ID NO: 1 or a fragment or derivative of the amino acid sequence of SEQ ID NO: 1. Additionally disclosed is a method of screening for biologically active agents that inhibit or promote isoQC.
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