Assays for Differentiating between Ischemic and Hemorrhagic Stroke in a Human Patient
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United States of America Patent
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Issued Date -
Mar 15, 2012
app pub date -
Sep 13, 2010
filing date -
Sep 13, 2010
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Abstract
Methods are disclosed for rapidly and reliably differentiating between ischemic and hemorrhagic stroke events in a human patient. The methods include obtaining a biological sample, such as blood serum, and analyzing the sample or a derivative thereof by mass spectrometry to measure the amount of one or more targeted proteins differentially present and ischemic and hemorrhagic stroke patients. The analysis may include proteolytic digestion of the biological sample and selective reaction monitoring (SRM) tandem mass spectrometry of the digested sample to determine the amounts of surrogate peptides corresponding to the targeted proteins.
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