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United States of America Patent
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Issued Date -
Mar 8, 2012
app pub date -
May 2, 2011
filing date -
Apr 30, 2010
priority date (Note) -
Abandoned
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Abstract
This invention provides methods for selectively antagonizing the α4β1 integrin heterodimer in a subject in need thereof, and preferably in a human subject. The methods of the invention utilize conjugates comprising two or more α4β1 small molecule antagonists covalently attached to a biocompatible polymer. These methods of selectively inhibiting α4β1 may be used modulate both normal and pathological biological processes mediated at least in part through α4β1 activity.
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