COMPOSITIONS AND METHODS FOR ELIMINATION OF GRAM NEGATIVE BACTERIA
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United States of America Patent
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Issued Date -
Mar 8, 2012
app pub date -
Mar 12, 2010
filing date -
Mar 13, 2009
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Abstract
Oral drug delivery formulations which specifically administer antibacterial agents to the ileum, caecum, and/or the colon, without significant administration elsewhere in the gastrointestinal tract, are disclosed. The formulations include, as actives, a combination of a macrolide or aminoglysoside, or quinolone antibacterial and an anti-Gram-negative lipopeptide (polymyxin) antibacterial agent or other peptide antibacterials effective against Gram-negative bacteria. The formulations can be used to treat infections or unwanted colonization in the colon, and to provide effective decontamination of the colonic flora from unwanted or potentially pathogenic bacteria.
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