SYSTEM AND METHOD FOR REVERTING ANTIBIOTIC TOLERANCE OF BACTERIAL PERSISTER CELLS
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United States of America Patent
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Issued Date -
Mar 1, 2012
app pub date -
Aug 9, 2011
filing date -
Aug 9, 2010
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Abstract
A system and method for reverting the antibiotic tolerance of persister cells. Brominated furanones, which are quorum sensing inhibitors, are used to revert the antibiotic tolerance of persister cells and enhance their susceptibility to antibiotics by up to one hundred fold. Brominated furanones can be used against bacterial persister cells in biofilms or planktonic form.
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