Administration of HB-EGF for the Protection of Enteric Neurons

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United States of America Patent

APP PUB NO 20120053121A1
SERIAL NO

12872961

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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The invention provides for methods of protecting neurons within the enteric nervous system (ENS) comprising administering an EGF receptor agonist, such as heparin-binding EGF (HB-EGF). These methods include reducing damage of ENS neurons in patient s suffering from an intestinal injury. In addition, the invention provides for increasing intestinal motility in a patient suffering from an intestinal injury comprising administering HB-EGF. The invention also provides for methods of inducing neurite growth within the ENS in a patient suffering from intestinal injury comprising administering HB-EGF.

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Patent Owner(s)

Patent OwnerAddress
NATIONWIDE CHILDREN'S HOSPITAL INCCOLUMBUS OH 43205

International Classification(s)

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  • 2010 Application Filing Year
  • A61K Class
  • 10962 Applications Filed
  • 7633 Patents Issued To-Date
  • 69.64 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances2010201120122013201420152016201720182019202020212022202320240255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
BESNER, GAIL E DUBLIN, US 19 111
ZHOU, YU UPPER ARLINGTON, US 454 2834

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Patent Citation Ranking

  • 8 Citation Count
  • A61K Class
  • 12.01 % this patent is cited more than
  • 13 Age
Citation count rangeNumber of patents cited in rangeNumber of patents cited in various citation count ranges842417611114322011046329171032401 - 1011 - 2021 - 3031 - 4041 - 5051 - 6061 - 7071 - 8081 - 9091 - 100100 +0250500750100012501500175020002250250027503000325035003750400042504500

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