METHODS AND COMPOSITIONS FOR SELECTING SIRNA OF IMPROVED FUNCTIONALITY

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United States of America Patent

APP PUB NO 20050255487A1
SERIAL NO

10940892

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Abstract

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Efficient sequence specific gene silencing is possible through the use of siRNA technology. By selecting particular siRNAs by rational design, one can maximize the generation of an effective gene silencing reagent, as well as methods for silencing genes. Methods, compositions, and kits generated through rational design of siRNAs are disclosed.

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Patent Owner(s)

  • THERMO FISHER SCIENTIFIC INC.

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  • 2004 Application Filing Year
  • C07H Class
  • 2105 Applications Filed
  • 497 Patents Issued To-Date
  • 23.62 % Issued To-Date
Click to zoom InYear of Issuance% of Matters IssuedCumulative IssuancesYearly Issuances200420052006200720082009201020112012201320142015201620170255075100

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Khvorova, Anastasia Boulder, US 393 10160
Leake, Devin Boulder, US 271 7128
Marshall, William Boulder, US 248 7212
Read, Steven Denver, US 219 4652
Reynolds, Angela Conifer, US 244 6997
Scaringe, Stephen Lafayette, US 232 6560

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  • 76 Citation Count
  • C07H Class
  • 97.49 % this patent is cited more than
  • 13 Age
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