PHOSPHOSPECIFIC PAK ANTIBODIES AND DIAGNOSTIC KITS
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United States of America Patent
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Issued Date -
Feb 23, 2012
app pub date -
Aug 18, 2011
filing date -
Nov 27, 2002
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Abstract
The present invention relates to the use of phosphorylated p21-activated protein kinases (PAK), especially PAK4, as biomarkers of tumorogenesis. The present invention contemplates the use of phosphospecific antibodies for detecting phosphorylated PAK from mammalian biopsies, as well as screening assays for identifying compounds that modulate PAK activity. Also contemplated is a method for determining a subset of a given population that is amenable to treatment with a compound that modulates PAK activity.
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