METHOD OF DETECTING PROGRESSION OF A NEURODEMENTING DISEASE
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United States of America Patent
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Issued Date -
Feb 16, 2012
app pub date -
Apr 5, 2011
filing date -
Jan 11, 2007
priority date (Note) -
Abandoned
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Abstract
Isolated, monoclonal, human, anti-β-amyloid antibodies are provided which bind to dimeric forms of Ab with higher affinity than to monomeric forms of Ab and when bound to an Aβ polypeptide comprising Aβ(21-37) shield Aβ(21-37) from proteolytic digestion. The antibodies were shown to inhibit fibril formation and reduce plaque size in vivo and to not bind brain vessel walls. Accordingly, the antibodies are useful in human and veterinary medicine for the treatment and prophylaxis of Alzheimer's disease and other neurodementing diseases. Methods of detecting or measuring the progression of a neurodementing disease also are provided.
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