TREATMENT OF RADIATION-INDUCED FIBROSIS
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United States of America Patent
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Issued Date -
Feb 16, 2012
app pub date -
Jan 28, 2010
filing date -
Jan 28, 2009
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Abstract
The present invention relates to treatment or prevention of radiation induced fibrosis using TNF-alpha antagonism. Preferably, TNF-alpha is antagonized by direct binding or by inhibition of synthesis. In a preferred embodiment, the invention comprises intraperitoneal administration of a chitosan-siRNA nanoparticle, wherein the siRNA is targeted to the mRNA encoding TNF-alpha.
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