T-Cell Receptor Antibodies And Methods of Use Thereof
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United States of America Patent
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Issued Date -
Feb 9, 2012
app pub date -
Oct 14, 2011
filing date -
Aug 26, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention is directed to the production and use of monoclonal antibodies, or antigen binding fragments thereof, that specifically bind the T cell antigen receptor (TCR) and their use for immunomodulation. In preferred embodiments, the antibody or antigen binding fragment of the invention specifically binds the constant region of the α chain of the TCR, or otherwise specifically binds the α chain regardless of TCR clonal origin (i.e., is pan specific for TCR). The antibodies of the invention may be used, for example, in immunosuppressive therapies for transplant maintenance and the treatment of autoimmune diseases, and/or as targeting molecules for use in the treatment of T-cell malignancies.
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