COMPOSITIONS FOR POTENTIATING APOPOSIS SIGNALS IN TUMOUR CELLS
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United States of America Patent
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Issued Date -
Feb 9, 2012
app pub date -
Dec 4, 2009
filing date -
Dec 4, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention concerns a composition for potentiating formation of DISC (Death Inducing Signaling Complex) macro-complex and for inducing apoptotic signal mediated by death receptors in tumour cells comprising a therapeutically effective amount of an active agent selected among a hypocalcemia-inducing agent, a calcium channel inhibitor and a calcium chelator in association with a therapeutically effective amount of an anticancer agent inducing an apoptotic signal via death receptors Fas, TNF-R1, DR4 and/or DR5.
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