Synthesis of Oligonucleotide Mediated Gold Core- Silver Shell Nanoparticles
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United States of America Patent
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Issued Date -
Jan 19, 2012
app pub date -
Mar 23, 2009
filing date -
Mar 23, 2009
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Abstract
The present invention relates to synthesis of oligonucleotide mediated gold core- silver shell nanoparticles and testing their SERS performance. A Raman reporter molecule and twelve-base long oligonucleotide are simultaneously attached on gold nanoparticles and a silver layer is deposited on the modified gold nanoparticles. The SERS performance of gold core- silver shell nanoparticles (CSNPs) is much greater than the CSNPs prepared without oligonucleotides and the same size non-modified gold nanoparticles after silver staining.
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