MicroRNA Modulators and Method for Identifying And Using The Same
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United States of America Patent
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Issued Date -
Jan 12, 2012
app pub date -
Aug 1, 2011
filing date -
Feb 20, 2008
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Abstract
The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
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