METHOD OF DISEASE-INDUCED AND RECEPTOR-MEDIATED STEM CELL NEUROPROTECTION

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United States of America Patent

SERIAL NO

13230354

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Abstract

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Stem cells are exposed to disease condition (the OGD stroke model), that mimics the target disease (stroke), allowing the stem cells to exert better neuroprotective effects. Thus, the present technology demonstrates a disease-tailored stem cell therapy. The present invention discloses that the administration of a therapeutically effective amount of amnion derived stem cells concomitantly with a therapeutically effective dose of melatonin provides additive/synergistic neuroprotective effects. Moreover, the present invention offers an equally robust technology employing a receptor-regulated mechanism, whereby stem cells can be enhanced (melatonin treatment) over their basal level (lack of melatonin treatment), facilitating a regulation of stem cells.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF SOUTH FLORIDA3802 SPECTRUM BLVD SUITE 100 TAMPA FL 33612
MEDICAL COLLEGE OF GEORGIA1120 15TH STREET CA 2126 AUGUSTA GA 30912-7624

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borlongan, Cesario V Tampa, US 14 78
Parolini, Ornella Brescia, IT 2 10

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