FcGammaRIIB Specific Antibodies and Methods of Use Thereof
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United States of America Patent
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Issued Date -
Jan 12, 2012
app pub date -
Sep 21, 2011
filing date -
Aug 14, 2002
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Abstract
The present invention relates to antibodies or fragments thereof that specifically bind FcγRIIB, particularly human FcγRIIB, with greater affinity than said antibodies or fragments thereof bind FcγRIIA, particularly human FcγRIIA. The invention provides methods of enhancing the therapeutic effect of therapeutic antibodies by administering the antibodies of the invention to enhance the effector function of the therapeutic antibodies. The invention also provides methods of enhancing efficacy of a vaccine composition by administering the antibodies of the invention.
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