Method For Amplification And Functional Enhancment Of Blood Derived Progenitor Cells Using A Closed Culture System

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United States of America Patent

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13164392

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Abstract

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The present invention provides a method for expanding and improving functional capacity of human adult-derived progenitor cells in vitro using a closed culture system. The present invention provides a favorable condition for cell therapy to promote tissue repair and organogenesis via vasculogenesis and angiogenesis in clinical settings. The proposed closed bag culture system for culturing hemangioblast comprises of, in one embodiment, a serum-free culture medium containing one or more factors selected from the group consisting of stem cell growth factor, interleukin-6, FMS-like tyrosine kinase 3, thrombopoietin, and vascular endothelial growth factor and a kit for the preparation of the serum-free culture medium and the like.

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UNIVERSITY HOSPITALS OF CLEVELAND11100 EUCLID AVENUE CLEVELAND OH 44106

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Asahara, Takayuki Tokyo, JP 27 458
Costa, Marco A Pepper Pike, US 3 341
Ishikawa, Masakazu Shaker Heights, US 44 226
Masuda, Haruchika Kanagawa, JP 5 45

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