COMPOSITIONS AND METHODS FOR ENHANCEMENT OF NUCLEIC ACID DELIVERY
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United States of America Patent
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Issued Date -
Dec 29, 2011
app pub date -
Jun 28, 2011
filing date -
Jun 29, 2010
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Abstract
Embodiments of the invention include devices and methods for delivery of nucleic acids as active agents. Embodiments of the invention include devices and methods for delivery of nucleic acids as active agents. In an embodiment, an article for delivering an active agent is included. The article can include a dehydrated complex including a nucleic acid, a transfection agent, and a saccharide protectant. The nucleic acid and transfection agent can form a liposome or a lipoplex. The dehydrated complex can be disposed within a polymeric matrix. The dehydrated complex can be disposed within a microparticle. Other embodiments are also included herein.
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