ANTIBODY PRODUCTION
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United States of America Patent
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Issued Date -
Dec 22, 2011
app pub date -
Nov 30, 2009
filing date -
Dec 18, 2008
priority date (Note) -
Abandoned
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Abstract
A non-human mammal containing an endogenous lambda light chain gene locus, an endogenous kappa light chain gene locus and an endogenous heavy chain gene locus, each of which can re-arrange so that immunoglobulin heavy and light chain genes are formed and expressed in B-cells following antigen challenge but said loci have been mutated so that the ability to form functional immunoglobulin tetramers comprising re-arranged heavy and light chains produced from said mutated loci has been substantially reduced or eliminated.
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