NON-INVASIVE IN VITRO METHOD FOR QUANTIFYING LIVER LESIONS
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Nov 18, 2009
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Nov 18, 2008
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Abstract
An in-vitro non-invasive method for quantifying the lesions of the liver of the patient with metabolic steatosis addressing a diagnostic target, i.e. fibrosis, steatosis and/or steato-hepatitis (NASH) and measuring at least one marker selected from the group consisting of biomarkers and possibly clinical markers and possibly scores, the biomarkers being selected from the group consisting of glycemia, AST (aspartate aminotransferase), ALT (alanine aminotransferase), AST/ALT, AST.ALT, ferritin, platelets, prothrombin index, hyaluronic acid, haemoglobin, triglycerides; the biomarker selected from weight, body mass index, sex and age, hip perimeter, abdominal perimeter and ratio thereof; the scores being selected from score of fibrosis, area of fibrosis, fractal dimension of fibrosis, score of steatosis, area of steatosis, fractal dimension of steatosis and combining the measures in a mathematical function combining the measures through a binary (or ordinal) logistic function or multiple linear regression including the markers in order to obtain an end value.
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