IgG-Fc FRAGMENT AND PROCESS FOR PRODUCING THE SAME
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United States of America Patent
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Issued Date -
Dec 22, 2011
app pub date -
Feb 9, 2010
filing date -
Feb 10, 2009
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Abandoned
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Abstract
A full-length IgG-Fc fragment having a substantially homogeneous sugar chain added thereto, and a process for producing the full-length IgG-Fc fragment. Specifically, an IgG-Fc fragment has a sugar chain added thereto, in which the sugar chain is added to the same position as that in a naturally occurring IgG-Fc fragment, any one amino acid residue selected from 1st to 30th amino acid residues from the sugar chain-added amino acid residue on the N-terminal side of the sugar chain-added amino acid residue is substituted by a Cys residue and at least one Met reside is substituted by an amino acid reside other than a Met residue.
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