METHODS AND SUBSTANCES FOR STIMULATING MUSCLE REGENERATION
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United States of America Patent
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Issued Date -
Dec 22, 2011
app pub date -
Aug 13, 2009
filing date -
Aug 13, 2008
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Abandoned
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Abstract
The invention is concerned with the field of muscle growth and regeneration. More particularly, the invention provides novel methods, substances and uses for facilitating the growth or regeneration of skeletal muscles. The methods, uses and substances of the invention are useful in the treatment or prevention of degenerative-regenerative muscular disorders or in the treatment of muscle injuries. The substances provided by the invention are capable of upregulating the calcineurin-NFAT-IL-4, advantageously by inhibiting the activity of the Ras or SERCA1b gene product. Introduction of the substances provided by the invention into only a small percentage of the fibers present in a regenerating muscle facilitates the regeneration of the whole muscle concerned.
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