METHODS AND APPARATUS FOR DISPLAYING PREDICTIONS ASSOCIATED WITH AN ALPHABETIC STRING

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United States of America Patent

APP PUB NO 20110307439A1
SERIAL NO

13140558

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Abstract

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The present disclosure provides methods and apparatus for displaying an alphabetic string representing an amino acid sequence of an antibody in association with predicted characteristics of certain sites in the antibody. In an embodiment, a process causes a web based application server to receive an alphabetic string from a client device indicative of an amino acid sequence. The server then predicts sites in the amino acid sequence likely to be associated with certain chemical properties such as deamidation, glycosylation, oxidation, proteolysis, and isomerization. The server may also predict other characteristics such as domain boundaries, binding sites, hydrophobicity levels, surface exposures, etc. The server then sends data to the client device indicative of the predicted sites and characteristics, so that the client device can display the alphabetic string indicative of the amino acid sequence with a graphical indication of the position of each predicted chemical property (e.g., with a semitransparent glyph over the associated alphabetic character).

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Patent Owner(s)

Patent OwnerAddress
XOMA TECHNOLOGY LTDBERKELEY CA 94710

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Evans, Mark Christopher Pleasant Hill, US 2 0

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