PROCESS FOR THE PREPARATION OF IMATINIB AND SALTS THEREOF
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United States of America Patent
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Issued Date -
Dec 15, 2011
app pub date -
Nov 18, 2010
filing date -
Dec 10, 2009
priority date (Note) -
Abandoned
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Abstract
Disclosed herein is a process for preparation of imatinib free base which comprises condensing 4-Methyl-N-(4-pyridin-3-yl-pyrimidin-2-yl)-benzene-1,3-diamine with 4-(4-Methyl-piperazin-1-ylmethyl)-benzoic acid ester in the presence of base including organic bases and inorganic bases in an organic solvent to form imatinib.
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