MACROLACTONE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF FOR THE TREATMENT OF CANCER
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United States of America Patent
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Issued Date -
Dec 15, 2011
app pub date -
Dec 10, 2009
filing date -
Dec 17, 2008
priority date (Note) -
Abandoned
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Abstract
The present invention relates to the use of a compound of the formula (I), wherein X and Y independently of one another are OH, O--(C.sub.1-C.sub.6)-alkyl, NH.sub.2 or NH--(C.sub.1-C.sub.6)-alkyl, or X and Y together form a group --O-- or wherein X and Y together form a further bond between the C atoms to which they are attached; R1 and R2 independently of one another are H, Cl or Br; R3 is H,(C.sub.1-C.sub.6)alkyl, C(.dbd.O)--(C.sub.1-C.sub.6)-alkyl or (C.sub.1-C.sub.6)-alkylene-NH--(C.sub.1-C.sub.6)-alkyl; R4 is H, (C.sub.1-C.sub.6)-alkyl or C(.dbd.O)--(C.sub.1-C.sub.6)-alkyl, and R5 is methyl or ethyl; or a physiologically tolerable salt of a compound of the formula (I), for the treatment and/or prophylaxis of cancer diseases, a pharmaceutical composition for the treatment and/or prophylaxis of cancer diseases comprising a compound of the formula (I), a compound of the formula (I) and a process for the preparation of the compound (I). ##STR00001##
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